Andrographis

Andrographis as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury

Andrographis is a medicinal herb that has been traditionally used in Ayurvedic and Traditional Chinese Medicine for its various health benefits. In the context of Drug-Induced Liver Injury (DILI), Andrographis has shown potential in protecting the liver from damage caused by certain medications or toxins.

Benefits of Andrographis in DILI:

  • Hepatoprotective Effects: Andrographis contains active compounds like andrographolides that have been found to have hepatoprotective properties. These compounds help in protecting the liver cells from damage and promoting their regeneration.
  • Anti-inflammatory Properties: In cases of DILI where inflammation plays a significant role in liver damage, Andrographis may help by reducing inflammation in the liver and preventing further injury.
  • Antioxidant Activity: Andrographis is known for its antioxidant properties, which can help in neutralizing free radicals and reducing oxidative stress in the liver, thus protecting it from damage.
  • Immune Modulation: Andrographis has immune-modulating effects that can help in regulating the immune response in the liver, potentially reducing the severity of DILI.
Overall, Andrographis shows promise as a natural remedy for supporting liver health and protecting against drug-induced liver injury. However, more research is needed to fully understand its mechanisms of action and effectiveness in the context of DILI. It is important to consult with a healthcare provider before using Andrographis or any other herbal supplement, especially if you have liver issues or are taking medications that may interact with it.

Supplements for DILI

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Green tea extract

    Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.

  2. Greater celandine

    Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.

  3. Chaparral

    Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.

  4. Germander

    Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.

  5. Mistletoe

    Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.

  6. Skullcap

    Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.

  7. Valerian

    Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.

  8. Kava kava

    Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.

  9. St. John's wort

    Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.

  10. Ginseng

    Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.

  11. Aloe vera

    Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.

  12. Ashwagandha

    Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.

  13. Andrographis

    Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.

  14. Noni juice

    Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.

  15. Peppermint oil

    Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.

  16. Kratom

    Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.

  17. Ephedra

    Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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