DR THOMAS' METHYLATION AND DETOX VARIANT REPORT

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SNP rsID Minor Allele RefSNP Alleles
ACAT1   rs3741049 A C/T
ACE Del16   rs4343 G A/G
AHCY-01   rs819147 C C/T
AHCY-19   rs819171 C C/T
AOC1 (DAO)   rs10156191 T C/T
APOE   rs429358 C C/T
APOE   rs7412 T C/T
BCO1   rs11645428 A A/G
BCO1   rs12934922 T A/T
BCO1   rs4889294 C C/T
BCO1   rs6564851 T G/T
BCO1   rs7501331 T C/T
BCO1 (PKD1L2)   rs6420424 G A/G
BHMT-02   rs567754 T C/T
BHMT-08   rs651852 T A/G
CAT   rs1049982 T C/T
CAT   rs11032703 T C/T
CAT   rs2300181 T A/G
CAT   rs480575 G C/T
CBS   rs28934891 T A/G
CBS A360A   rs1801181 A C/T
CBS C19150T   rs4920037 A A/G
CBS C699T   rs234706 A A/G
CD14   rs2569191 C C/T
CTH   rs1021737 T G/T
CTLA4   rs231775 G A/G
CYP1A1   rs1048943 C A/C/G/T
CYP1A1   rs1799814 T A/C
CYP1A1   rs4986883 C A/G
CYP1B1 L432V   rs1056836 C C/G
CYP1B1 N453S   rs1800440 C A/G
CYP1B1 R48G   rs10012 C C/G
CYP2E1*1B G9896C   rs2070676 G C/G
DAO   rs2070586 A A/G
DAO   rs3741775 C G/T
DAO   rs3918347 G A/G
DHFR   rs1643649 C C/T
F11   rs2289252 T C/T
FADS1   rs174548 G C/G
FADS1 (MYRF)   rs174537 T G/T
FADS2   rs1535 G A/G
FOLR1   rs2071010 A A/G
FOLR2   rs651933 G A/G
FOLR3   rs7925545 G A/G
FOXE1   rs10984009 A A/G
FOXE1   rs1867277 A A/G
FUT2   rs492602 G C/T
FUT2   rs601338 A A/G
FUT2   rs602662 A A/G
G6PD   rs1050828 T A/G
G6PD   rs1050829 C A/G
G6PD   rs5030868 A C/T
GAD1   rs10432420 A A/G
GAD1   rs12185692 A A/C
GAD1   rs2058725 C A/G
GAD1   rs2241165 C A/G
GAD1   rs3749034 A C/T
GAD1   rs3791850 A C/T
GAD1   rs3791851 C A/G
GAD1   rs3791878 T A/C
GAD1   rs701492 T C/T
GAD1   rs769407 C C/G
GAMT   rs17851582 A A/G
GAMT   rs55776826 T C/T
GIF   rs558660 A C/T
GPX1   rs1050450 A C/T
GSTM1   rs1056806 T C/T
GSTP1   rs1138272 T C/T
GSTP1   rs1695 G A/G
HFE   i3002468 - -
HFE   rs1799945 G C/G
HFE   rs1800562 A A/G
HLA   rs2858331 G C/T
HLA-DQA1   rs2187668 T A/G
HLA-DQA2   rs9275224 A A/G
HNMT   rs1050891 G C/T
HNMT   rs1378321 G C/T
IDO1   rs35099072 A C/T
IL5   rs2069812 G C/T
LRRK2   rs34637584 A A/G
MAO A R297R   rs6323 G G/T
MAOA   rs1137070 T C/T
MAOB   rs1799836 C A/G
MAT1A   rs1985908 A C/T
MAT1A   rs2993763 G A/G
MAT1A   rs72558181 - -
MIR4761 (COMT -61 P199P)   rs769224 A A/G
MIR4761 (COMT H62H)   rs4633 T C/T
MIR4761 (COMT V158M)   rs4680 A A/G
MPO   rs2071409 G A/C
MPO   rs28730837 A C/T
MTHFD1 C105T   rs1076991 T A/G
MTHFD1 G1958A   rs2236225 A C/T
MTHFD1L   rs11754661 A A/G
MTHFD1L   rs17349743 C C/T
MTHFD1L   rs6922269 A A/G
MTHFD1L   rs803422 A C/T
MTHFR A1298C   rs1801131 G A/C
MTHFR C677T   rs1801133 A C/T
MTHFS   rs2733103 T A/G
MTHFS   rs6495446 T C/T
MTR A2756G   rs1805087 G A/G
MTRR   rs1532268 T A/G
MTRR   rs1801394 G A/G
MTRR K350A   rs162036 G A/G
MTRR-11 A664A   rs1802059 A A/G
MUT   rs6458690 G A/G
NAT1   rs4986782 A A/G
NAT2   rs1799930 A A/G
NAT2   rs1799931 A A/G
NAT2   rs1801279 A A/G
NAT2   rs1801280 C C/T
NDUFS3   rs4147730 A A/G
NDUFS7   rs1142530 T C/T
NDUFS7   rs2332496 A A/G
NDUFS7   rs809359 G A/G
NDUFS8   rs1051806 T C/G/T
NDUFS8   rs2075626 C C/T
NDUFS8   rs999571 A C/T
NOS1   rs2293054 A A/G
NOS1   rs7298903 C C/T
NOS2   rs2248814 A A/G
NOS2   rs2274894 T G/T
NOS3   rs1799983 T G/T
NOS3   rs1800779 G A/G
NOS3   rs1800783 A A/T
NOS3   rs3918188 A A/C/T
NQO1   rs1131341 A C/G/T
NQO1   rs1437135 G A/G
NQO1   rs1800566 A C/T
PEMT   rs4244593 T A/C
PEMT   rs4646406 A A/T
PEMT   rs7946 T C/T
PNMT   rs5638 G A/G
PNMT   rs876493 A C/T
PON1   rs662 T A/G
SHMT1 C1420T   rs1979277 A A/G
SHMT2   rs34095989 A A/G
SLC19A1   rs1051266 C A/G
SOD2   rs2758331 A A/C
SOD2   rs4880 G C/T
SOD3   rs1799895 G C/G
SOD3   rs2855262 C C/T
SULT1A1   i6018900 - -
SULT1A1   rs1042157 A C/G/T
SUOX   rs705703 T C/T
SUOX   rs773115 G A/C/G
TCN1   rs526934 G A/G
TCN2 C766G   rs1801198 G C/G
TNF   rs1800629 A A/G
VDR   rs2228570 A A/C/G/T
VDR   rs731236 G C/T
VDR Bsm   rs1544410 T A/G
Genome Wide Studies
  • Study on rs4343 - Blood metabolite ratios.  Reduced Risk in people with AA genotype ( Odds Ratio: 0.06 ).

    An atlas of genetic influences on human blood metabolites.

    Population: Up to 1,767 European ancestry individuals ( Replicated in another study with Up to 1,767 European ancestry individuals )

    Pubmed reference: 24816252


  • Study on rs429358 - Alzheimer's disease biomarkers. 

    Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.

    Population: None )

    Pubmed reference: 21123754


  • Study on rs7412 - Response to statin therapy (LDL-C). 

    Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.

    Population: None )

    Pubmed reference: 22331829


  • Study on rs4889294 - Protein quantitative trait loci. 

    A genome-wide association study identifies protein quantitative trait loci (pQTLs).

    Population: up to 4,590 European ancestry individuals ( Replicated in another study with up to 4,590 European ancestry individuals )

    Pubmed reference: 18464913


  • Study on rs6564851 - Carotenoid and tocopherol levels.  Reduced Risk in people with GG genotype ( Odds Ratio: 0.15 ).

    Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

    Population: 2,540 European ancestry individuals, 211 individuals ( Replicated in another study with 2,540 European ancestry individuals, 211 individuals )

    Pubmed reference: 19185284


  • Study on rs2289252 - Activated partial thromboplastin time.  Reduced Risk in people with CC genotype ( Odds Ratio: 0.48 ).

    Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.

    Population: 2611 European ancestry individuals ( Replicated in another study with 2611 European ancestry individuals )

    Pubmed reference: 22703881


  • Study on rs174548 - Metabolite levels. 

    Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

    Population: None )

    Pubmed reference: 19043545


  • Study on rs174537 rs4246215 rs174550 rs1535 - Colorectal cancer.  Increased Risk in people with GG genotype ( Odds Ratio: 1.16 ).

    Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

    Population: 12,865 East Asian ancestry cases, 25,773 East Asian ancestry controls, up to 16,984 European ancestry cases, up to 18,262 European ancestry controls ( Replicated in another study with 12,865 East Asian ancestry cases, 25,773 East Asian ancestry controls, up to 16,984 European ancestry cases, up to 18,262 European ancestry controls )

    Pubmed reference: 24836286


  • Study on rs1535 - Metabolic syndrome.  Reduced Risk in people with GG genotype ( Odds Ratio: 0.03 ).

    A genome-wide association study of the metabolic syndrome in Indian Asian men.

    Population: 2,240 Indian Asian ancestry individuals ( Replicated in another study with 2,240 Indian Asian ancestry individuals )

    Pubmed reference: 20694148


  • Study on rs492602 - Vitamin B12 levels.  Reduced Risk in people with GG genotype ( Odds Ratio: 0.09 ).

    Common variants of FUT2 are associated with plasma vitamin B12 levels.

    Population: 1,059 European ancestry female individuals ( Replicated in another study with 1,059 European ancestry female individuals )

    Pubmed reference: 18776911


  • Study on rs601338 - Blood metabolite ratios.  Reduced Risk in people with AA genotype ( Odds Ratio: 0.06 ).

    An atlas of genetic influences on human blood metabolites.

    Population: Up to 1,767 European ancestry individuals ( Replicated in another study with Up to 1,767 European ancestry individuals )

    Pubmed reference: 24816252


  • Study on rs602662 - Folate pathway vitamin levels. 

    Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.

    Population: None )

    Pubmed reference: 19744961


  • Study on rs1050828 - Red blood cell traits.  Increased Risk in people with AA genotype ( Odds Ratio: 2.46 ).

    Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study.

    Population: 411 African American individuals ( Replicated in another study with 411 African American individuals )

    Pubmed reference: 23696099


  • Study on rs1799945 - Hypertension.  Reduced Risk in people with GG genotype ( Odds Ratio: 0.1 ).

    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

    Population: Up to 133,361 European ancestry individuals ( Replicated in another study with Up to 133,361 European ancestry individuals )

    Pubmed reference: 21909115


  • Study on rs1800562 - Iron status biomarkers.  Reduced Risk in people with AA genotype ( Odds Ratio: 0.2 ).

    Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.

    Population: 3,470 European ancestry individuals ( Replicated in another study with 3,470 European ancestry individuals )

    Pubmed reference: 19820699


  • Study on rs2858331 - IgE levels. 

    A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.

    Population: 2,961 African American individuals, 1,477 Latino individuals, 649 European ancestry individuals, 680 Hutterite individuals ( Replicated in another study with 2,961 African American individuals, 1,477 Latino individuals, 649 European ancestry individuals, 680 Hutterite individuals )

    Pubmed reference: 23146381


  • Study on rs2187668 - Systemic lupus erythematosus. 

    Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

    Population: 793 European ancestry cases, 857 European ancestry controls ( Replicated in another study with 793 European ancestry cases, 857 European ancestry controls )

    Pubmed reference: 18204098


  • Study on rs34637584 - Parkinson's disease.  Increased Risk in people with AA genotype ( Odds Ratio: 9.62 ).

    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.

    Population: None )

    Pubmed reference: 21738487


  • Study on rs4680 - Blood metabolite levels.  Reduced Risk in people with AA genotype ( Odds Ratio: 0.04 ).

    An atlas of genetic influences on human blood metabolites.

    Population: None )

    Pubmed reference: 24816252


  • Study on rs11754661 - Alzheimer's disease (late onset).  Increased Risk in people with AA genotype ( Odds Ratio: 2.1 ).

    Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.

    Population: 1,338 cases, 2,003 controls ( Replicated in another study with 1,338 cases, 2,003 controls )

    Pubmed reference: 20885792


  • Study on rs6922269 - Coronary heart disease.  Increased Risk in people with AA genotype ( Odds Ratio: 1.23 ).

    Genomewide association analysis of coronary artery disease.

    Population: 875 European ancestry cases, 1,644 European ancestry controls ( Replicated in another study with 875 European ancestry cases, 1,644 European ancestry controls )

    Pubmed reference: 17634449


  • Study on rs1801133 - Homocysteine levels.  Reduced Risk in people with AA genotype ( Odds Ratio: 0.16 ).

    Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

    Population: None )

    Pubmed reference: 23824729


  • Study on rs526934 - Folate pathway vitamin levels. 

    Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.

    Population: None )

    Pubmed reference: 19744961