Mold? CHRONIC INFLAMMATORY RESPONSE SYNDROME (CIRS) MOLDHLA-DRB1, HLA-DQB1, HLA-DRB3, HLA-DRB4 (NONE), HLA-DRB5

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SNP rsID Minor Allele RefSNP Alleles
HLA   rs7775228 C C/T
HLA-DQB1   rs1063355 T A/C
HLA-DQB1   rs2854275 A G/T
HLA-DQB1   rs28688207 C C/T
HLA-DQB1   rs4988889 T G/T
HLA-DQB1   rs9273373 A A/G
HLA-DQB1   rs9274407 A A/T
HLA-DQB1   rs9274477 G A/G
HLA-DRB1   rs113322920 C C/T
HLA-DRB1   rs149121504 C C/T
HLA-DRB1   rs28723983 G A/G
HLA-DRB1   rs35445101 G A/G
HLA-DRB1   rs660895 G A/G
HLA-DRB1   rs707953 C A/G
HLA-DRB1   rs72844253 G G/T
HLA-DRB3   rs2157337 T A/G
HLA-DRB5   rs144115779 C C/T
HLA-DRB5   rs146225755 A A/G
HLA-DRB5   rs41553512 T A/G
R S
R S  

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These are the genes tested to determine multiple susceptibilities to various biotoxins according to Dr. Shoemaker's Chronic Inflammatory Response Syndrome (CIRS) work as found in Surviving Mold and survivingmold.com.


Genome Wide Studies
  • Study on rs7775228 - Asthma.  Increased Risk in people with AA genotype ( Odds Ratio: 1.17 ).

    Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.

    Population: 5,639 Japanese ancestry cases, 24,608 Japanese ancestry controls ( Replicated in another study with 5,639 Japanese ancestry cases, 24,608 Japanese ancestry controls )

    Pubmed reference: 21804548


  • Study on rs2854275 - Epstein-Barr virus immune response (EBNA-1).  Reduced Risk in people with TT genotype ( Odds Ratio: 0.45 ).

    A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

    Population: 589 Mexican American indivduals ( Replicated in another study with 589 Mexican American indivduals )

    Pubmed reference: 23326239


  • Study on rs9273373 - Asthma and hay fever.  Increased Risk in people with GG genotype ( Odds Ratio: 1.24 ).

    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

    Population: 878 European ancestry cases, 2,455 European ancestry controls ( Replicated in another study with 878 European ancestry cases, 2,455 European ancestry controls )

    Pubmed reference: 24388013


  • Study on rs9274407 - Drug-induced liver injury (amoxicillin-clavulanate). 

    Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.

    Population: None )

    Pubmed reference: 21570397


  • Study on rs9274477 - Narcolepsy (age of onset).  Increased Risk in people with GG genotype ( Odds Ratio: 1.82 ).

    Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.

    Population: None )

    Pubmed reference: 24204295


  • Study on rs660895 - Rheumatoid arthritis. 

    TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

    Population: 1,053 European ancestry cases, 1,858 European ancestry controls ( Replicated in another study with 1,053 European ancestry cases, 1,858 European ancestry controls )

    Pubmed reference: 17804836


  • Study on rs2157337 - Rheumatoid arthritis. 

    A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

    Population: 887 European ancestry ACPA positive RA cases, 1,218 European ancestry controls ( Replicated in another study with 887 European ancestry ACPA positive RA cases, 1,218 European ancestry controls )

    Pubmed reference: 21156761