Pharmacogenomics Case Studies

Fictional-but-clinically-grounded pharmacogenomics case studies.

• Eight years. Four SSRIs. None of them worked. Here's why. — A fictional case study: Kofi tried four SSRIs over eight years and got no relief. His results showed that standard doses were being cleared too quickly to work, while side effects appeared when doses were pushed higher.
• One codeine tablet hit like far more — A fictional case study: Brigid is a nurse prescribed codeine 30mg after minor surgery. Within an hour she had extreme nausea, dizziness, drowsiness, and confusion. Her CYP2D6 result showed that her body turns codeine into morphine unusually fast, changing the safety of future prescriptions.
• Her pill was common. Her clot risk was not. — A fictional case study: Yasmin develops a DVT at 26 while on the combined oral contraceptive pill. Her Factor V Leiden variant and the pill each raise clot risk; together they multiply it. A genetics-informed review explains what happened, which contraception options remain safer, and what her family may need to know.