Methamphetamine is a powerful stimulant drug that is commonly abused. It is known to produce a range of psychological and physical effects, including increased alertness, euphoria, and increased energy. However, long-term use of methamphetamine can lead to serious mental health problems, including psychosis. Studies have found that individuals who use methamphetamine are more likely to have a genetic variant of the DTNBP1 gene, which is associated with an increased risk of developing psychosis. The DTNBP1 gene, also known as dysbindin, is a gene that has been linked to an increased risk of developing psychosis. The gene is located on chromosome 6 and is involved in the regulation of dopamine and glutamate neurotransmission. It has been found to be associated with schizophrenia, bipolar disorder, and other psychotic disorders. The combination of the DTNBP1 gene and methamphetamine use has been found to be associated with an increased risk of developing psychosis. Studies have found that individuals who have the genetic variant of the DTNBP1 gene and use methamphetamine are more likely to develop psychotic symptoms than those who do not have the genetic variant and do not use methamphetamine. One study investigated the association between the dysbindin (DTNBP1) gene and methamphetamine psychosis. Results showed that two polymorphisms (P1635 and SNPA) and a three-locus haplotype of P1655-P1635-SNPA were significantly associated with methamphetamine psychosis. The C-A-A haplotype, which was previously reported to be protective for schizophrenia and psychotic bipolar disorders, was found to be a protective factor for methamphetamine psychosis. The C-G-T haplotype was a risk factor for methamphetamine psychosis. These findings suggest that DTNBP1 is involved in psychotic liability not only for schizophrenia but also for other psychotic disorders, including substance-induced psychosis. It is important to note that the DTNBP1 gene and methamphetamine use are not the only factors that can increase the risk of developing psychosis. Other factors such as family history, environmental factors, and other genetic factors can also play a role in the development of psychosis.