EGCG
EGCG as it relates to Longevity in Health report: The Fountain of Youth: How Sirtuins Affect Aging
EGCG and Longevity
EGCG (Epigallocatechin gallate) is a powerful antioxidant found in green tea that has been studied for its potential benefits in promoting longevity and overall health.
Research has shown that EGCG can help protect cells from damage caused by free radicals, which are unstable molecules that can contribute to aging and various diseases. By neutralizing these free radicals, EGCG may help slow down the aging process and reduce the risk of age-related diseases.
In addition to its antioxidant properties, EGCG has also been found to have anti-inflammatory and anti-cancer effects. Chronic inflammation and cancer are both factors that can contribute to premature aging, so the ability of EGCG to combat these issues may further support longevity.
Furthermore, EGCG has been linked to improvements in cardiovascular health, brain function, and metabolism, all of which are important factors in maintaining overall health and longevity.
Overall, while more research is needed to fully understand the mechanisms by which EGCG may promote longevity, the existing evidence suggests that incorporating green tea or EGCG supplements into your daily routine may have positive effects on your health and lifespan.
Supplements for Longevity
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
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Resveratrol
This polyphenol compound found in grape skins and red wine has been shown to activate SIRT1 in cellular studies. However, required dosing to reach pharmacologically active doses in humans remains unclear.
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Quercetin
This flavonoid in some fruits and vegetables may activate SIRT1 similar to resveratrol while also having strong anti-inflammatory effects that could promote healthy aging.
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Nicotinamide Riboside
This NAD+ precursor supplement showed promising results in a small 2020 human trial, increasing NAD+ levels and SIRT1 gene expression after just 2 weeks. Larger trials are still needed.
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Astragalus
Used in traditional Chinese medicine, extracts of this herb have exhibited ability to induce SIRT1 activity in rodent studies. The main bioactive compounds appear to be saponins and polysaccharides.
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Curcumin
Major constituent of turmeric spice. Has exhibited sirtuin-activating properties in lab studies, potentially through enzyme inhibition related to inflammatory pathways. Also boosts antioxidant capacity.
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EGCG
Abbreviation for epigallocatechin gallate, a compound in green tea. Has shown significant lifespan extension in studies of yeast, roundworms and fruit flies, perhaps partially by mimicking effects of calorie restriction on sirtuin genes.
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Ginsenosides (from ginseng)
Compounds found in ginseng root, such as Rb1, Rg1, Re, and Rg3 ginsenosides have exhibited an ability to induce SIRT1 expression in animal and cell studies. This may contribute to reported anti-aging effects.
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Piceatannol
Natural stilbenoid compound found in passionfruit peel, sugarcane, and grapes. Shown to activate SIRT1 at lower concentrations than resveratrol in one lab study with human cell cultures.
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Omega-3 fatty acids
DHA omega-3s in particular may activate sirtuins and downregulate inflammatory genes involved in the aging process. Found primarily in fatty fish. Fish oil supplements may provide anti-aging benefits.
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Theanine
Abundant amino acid in green tea linked to increased lifespan in nematodes. Thought to act as a natural SIRT1 activator, at least in mouse studies. Could contribute to tea's anti-aging effects.
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Glucoraphanin
Phytochemical found prominently in broccoli sprouts that enhances NAD+ bioavailability for sirtuin activation through metabolic pathways. Also boosts production of antioxidants.
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Pyrroloquinoline quinone (PQQ)
Compound found in plant foods that has shown ability to stimulate mitochondrial biogenesis - creation of new mitochondria. This aligns with sirtuin function and protection against aging.
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