Omega-3 fatty acids

Omega-3 fatty acids as it relates to Longevity in Health report: The Fountain of Youth: How Sirtuins Affect Aging

Omega-3 fatty acids are essential nutrients that play a crucial role in promoting longevity and overall health. These polyunsaturated fats are known for their anti-inflammatory properties, which can help reduce the risk of chronic diseases and age-related conditions.

Benefits of Omega-3 fatty acids for Longevity:

  • Heart Health: Omega-3 fatty acids have been shown to lower the risk of heart disease by reducing inflammation, lowering blood pressure, and improving cholesterol levels.
  • Brain Function: DHA, a type of Omega-3 fatty acid, is a major component of the brain and has been linked to improved cognitive function and a reduced risk of neurodegenerative diseases.
  • Joint Health: Omega-3 fatty acids can help reduce inflammation in the joints, which may alleviate symptoms of arthritis and improve mobility in older adults.
  • Skin Health: These fatty acids can help maintain skin elasticity, hydration, and overall appearance, which can contribute to a more youthful complexion.
  • Cellular Health: Omega-3 fatty acids play a role in maintaining the integrity of cell membranes and supporting cellular function, which is essential for overall longevity.
Incorporating sources of Omega-3 fatty acids, such as fatty fish (salmon, mackerel, sardines), flaxseeds, chia seeds, and walnuts, into your diet can help support longevity and promote overall well-being. Additionally, Omega-3 supplements are available for those who may have difficulty obtaining enough through dietary sources.

Supplements for Longevity

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Resveratrol

    This polyphenol compound found in grape skins and red wine has been shown to activate SIRT1 in cellular studies. However, required dosing to reach pharmacologically active doses in humans remains unclear.

  2. Quercetin

    This flavonoid in some fruits and vegetables may activate SIRT1 similar to resveratrol while also having strong anti-inflammatory effects that could promote healthy aging.

  3. Nicotinamide Riboside

    This NAD+ precursor supplement showed promising results in a small 2020 human trial, increasing NAD+ levels and SIRT1 gene expression after just 2 weeks. Larger trials are still needed.

  4. Astragalus

    Used in traditional Chinese medicine, extracts of this herb have exhibited ability to induce SIRT1 activity in rodent studies. The main bioactive compounds appear to be saponins and polysaccharides.

  5. Curcumin

    Major constituent of turmeric spice. Has exhibited sirtuin-activating properties in lab studies, potentially through enzyme inhibition related to inflammatory pathways. Also boosts antioxidant capacity.

  6. EGCG

    Abbreviation for epigallocatechin gallate, a compound in green tea. Has shown significant lifespan extension in studies of yeast, roundworms and fruit flies, perhaps partially by mimicking effects of calorie restriction on sirtuin genes.

  7. Ginsenosides (from ginseng)

    Compounds found in ginseng root, such as Rb1, Rg1, Re, and Rg3 ginsenosides have exhibited an ability to induce SIRT1 expression in animal and cell studies. This may contribute to reported anti-aging effects.

  8. Piceatannol

    Natural stilbenoid compound found in passionfruit peel, sugarcane, and grapes. Shown to activate SIRT1 at lower concentrations than resveratrol in one lab study with human cell cultures.

  9. Omega-3 fatty acids

    DHA omega-3s in particular may activate sirtuins and downregulate inflammatory genes involved in the aging process. Found primarily in fatty fish. Fish oil supplements may provide anti-aging benefits.

  10. Theanine

    Abundant amino acid in green tea linked to increased lifespan in nematodes. Thought to act as a natural SIRT1 activator, at least in mouse studies. Could contribute to tea's anti-aging effects.

  11. Glucoraphanin

    Phytochemical found prominently in broccoli sprouts that enhances NAD+ bioavailability for sirtuin activation through metabolic pathways. Also boosts production of antioxidants.

  12. Pyrroloquinoline quinone (PQQ)

    Compound found in plant foods that has shown ability to stimulate mitochondrial biogenesis - creation of new mitochondria. This aligns with sirtuin function and protection against aging.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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