Resveratrol
Resveratrol as it relates to Longevity in Health report: The Fountain of Youth: How Sirtuins Affect Aging
Resveratrol and Longevity
Resveratrol is a natural compound found in certain plants, such as grapes, blueberries, and peanuts. It has gained attention for its potential health benefits, including its role in promoting longevity.
Studies have shown that resveratrol has antioxidant and anti-inflammatory properties, which can help protect cells from damage and reduce the risk of chronic diseases associated with aging. It has also been found to activate sirtuins, a group of proteins that play a key role in regulating cellular health and longevity.
Research on resveratrol and longevity is still ongoing, but some studies have suggested that it may have anti-aging effects by improving metabolic function, reducing inflammation, and enhancing cellular repair mechanisms. However, more research is needed to fully understand the impact of resveratrol on longevity in humans.
Overall, incorporating resveratrol-rich foods or supplements into your diet may have potential benefits for promoting longevity and overall health. It is always recommended to consult with a healthcare provider before starting any new supplement regimen.
Supplements for Longevity
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
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Resveratrol
This polyphenol compound found in grape skins and red wine has been shown to activate SIRT1 in cellular studies. However, required dosing to reach pharmacologically active doses in humans remains unclear.
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Quercetin
This flavonoid in some fruits and vegetables may activate SIRT1 similar to resveratrol while also having strong anti-inflammatory effects that could promote healthy aging.
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Nicotinamide Riboside
This NAD+ precursor supplement showed promising results in a small 2020 human trial, increasing NAD+ levels and SIRT1 gene expression after just 2 weeks. Larger trials are still needed.
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Astragalus
Used in traditional Chinese medicine, extracts of this herb have exhibited ability to induce SIRT1 activity in rodent studies. The main bioactive compounds appear to be saponins and polysaccharides.
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Curcumin
Major constituent of turmeric spice. Has exhibited sirtuin-activating properties in lab studies, potentially through enzyme inhibition related to inflammatory pathways. Also boosts antioxidant capacity.
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EGCG
Abbreviation for epigallocatechin gallate, a compound in green tea. Has shown significant lifespan extension in studies of yeast, roundworms and fruit flies, perhaps partially by mimicking effects of calorie restriction on sirtuin genes.
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Ginsenosides (from ginseng)
Compounds found in ginseng root, such as Rb1, Rg1, Re, and Rg3 ginsenosides have exhibited an ability to induce SIRT1 expression in animal and cell studies. This may contribute to reported anti-aging effects.
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Piceatannol
Natural stilbenoid compound found in passionfruit peel, sugarcane, and grapes. Shown to activate SIRT1 at lower concentrations than resveratrol in one lab study with human cell cultures.
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Omega-3 fatty acids
DHA omega-3s in particular may activate sirtuins and downregulate inflammatory genes involved in the aging process. Found primarily in fatty fish. Fish oil supplements may provide anti-aging benefits.
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Theanine
Abundant amino acid in green tea linked to increased lifespan in nematodes. Thought to act as a natural SIRT1 activator, at least in mouse studies. Could contribute to tea's anti-aging effects.
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Glucoraphanin
Phytochemical found prominently in broccoli sprouts that enhances NAD+ bioavailability for sirtuin activation through metabolic pathways. Also boosts production of antioxidants.
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Pyrroloquinoline quinone (PQQ)
Compound found in plant foods that has shown ability to stimulate mitochondrial biogenesis - creation of new mitochondria. This aligns with sirtuin function and protection against aging.
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