Glucomannan

Glucomannan as it relates to Ghrelin and FTO in Health report: The Hunger Hormone - How Genetics Influence Our Appetite and Weight

Glucomannan is a water-soluble dietary fiber that is derived from the root of the konjac plant. It is known for its ability to absorb water and expand in the stomach, helping to promote a feeling of fullness and reduce appetite. Research has shown that glucomannan may also have an impact on the hunger hormone ghrelin. Ghrelin is produced in the stomach and signals to the brain that it's time to eat. By expanding in the stomach, glucomannan can potentially help to reduce the levels of ghrelin, leading to decreased feelings of hunger and ultimately aiding in weight management. Additionally, studies have suggested that glucomannan may interact with the FTO gene, which is associated with obesity. The FTO gene is involved in the regulation of energy balance and appetite, and variations in this gene have been linked to an increased risk of obesity. Glucomannan's ability to promote satiety and potentially influence ghrelin levels may help to mitigate the effects of certain FTO gene variants on weight gain. Overall, incorporating glucomannan into a balanced diet may be beneficial for those looking to manage their weight by helping to control appetite, regulate hunger hormones like ghrelin, and potentially interact with genes like FTO that are associated with obesity. References: 1. Salas-Salvadó J, Farrés X, Luque X, et al. Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial. Br J Nutr. 2008;99(6):1380-1387. doi:10.1017/S0007114507877646 2. Qi Q, Chu AY, Kang JH, et al. Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med. 2012;367(15):1387-1396. doi:10.1056/NEJMoa1203039

Supplements for Ghrelin and FTO

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Green Tea Extract

    Green tea is rich in antioxidants called catechins, which have been shown to increase metabolism and promote fat burning. It also contains caffeine, which can help boost energy levels and improve performance during exercise.

  2. Garcinia Cambogia

    This tropical fruit extract is believed to inhibit an enzyme that your body uses to make fat. It also raises levels of serotonin, potentially helping to reduce cravings.

  3. Glucomannan

    Derived from the konjac plant, glucomannan is a type of dietary fiber that can absorb water and form a gel, which can help you feel fuller and eat less.

  4. Caffeine

    Often found in weight loss supplements and energy drinks, caffeine can help boost metabolism and increase fat burning. However, it can also lead to sleep disturbances and other side effects.

  5. Raspberry Ketones

    These are natural substances that give raspberries their powerful aroma. They are also found in kiwis, peaches, grapes, and other berries. Raspberry ketones in food and cosmetics are generally considered safe, but their effect on weight loss in humans is still being researched.

  6. Forskolin

    This is a compound found in the root of the Coleus forskohlii plant. It is believed to help promote weight loss by creating enzymes called lipase and adenylate cyclase, which free fatty acids from the body's cells.

  7. Conjugated Linoleic Acid (CLA)

    CLA is a type of polyunsaturated fat that is often marketed as a weight loss supplement. It is found naturally in beef and dairy products. Some studies suggest that CLA can help reduce body fat and increase muscle mass, but other research has shown mixed results.

  8. Bitter Orange

    Bitter orange contains several chemical compounds that may stimulate metabolic rate and increase calorie burning in the body. However, it can also increase heart rate and blood pressure, leading to potential health risks.

  9. Hoodia Gordonii

    This is a type of succulent plant traditionally used by indigenous people in southern Africa to suppress appetite during long hunting trips. However, there's little scientific evidence to support these claims, and it may have side effects like liver damage.

  10. 5-HTP

    This is a compound that your body makes from tryptophan, an essential amino acid. It's used to produce serotonin, a chemical that has a variety of functions in the body. As a supplement, 5-HTP is often used for appetite suppression and weight loss.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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