Cannabidiol (CBD)

Cannabidiol (CBD) as it relates to Chronic Pain in Health report: COMT and Chronic Pain Susceptibility

Cannabidiol (CBD) for Chronic Pain

Cannabidiol (CBD) is a chemical compound found in the cannabis plant. It has been gaining popularity in recent years for its potential therapeutic benefits, especially in managing chronic pain.

Research suggests that CBD may help reduce pain and inflammation by interacting with the endocannabinoid system in the body. This system plays a key role in regulating various functions, including pain sensation, immune response, and mood.

Many people with chronic pain conditions, such as arthritis, fibromyalgia, and neuropathy, have reported finding relief with CBD products. These can include oils, tinctures, capsules, and topical creams.

It's important to note that while some studies have shown promising results, more research is needed to fully understand the effectiveness of CBD for chronic pain. Additionally, the legality of CBD products can vary depending on where you live.

If you are considering using CBD for chronic pain, it's recommended to consult with a healthcare provider to discuss the potential benefits and risks, as well as to determine the appropriate dosage and form of CBD for your specific needs.

Supplements for Chronic Pain

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Curcumin (turmeric)

    Shown to inhibit COMT activity and increase dopamine levels in the brain. Also has anti-inflammatory effects.

  2. Omega-3 fatty acids (fish oil):

    May reduce inflammation that contributes to pain. Also may protect neurons that use dopamine.

  3. Magnesium

    Required for COMT enzymatic reactions. Supplements may help for those deficient.

  4. Rhodiola rosea

    Herb that may inhibit COMT, especially in the Met/Met genotype. May prolong dopamine effects.

  5. SAM-e

    Supplement that provides methyl groups needed for COMT methylation reactions. May support COMT function.

  6. Devil's claw

    Natural anti-inflammatory that may reduce inflammatory pain. Also thought to interact with neurotransmitter systems.

  7. Cayenne/Capsaicin

    Compound found in hot chili peppers that depletes substance P, a neurotransmitter involved in pain signaling.

  8. Valerian root

    Herbal anxiolytic that may increase GABA, a neurotransmitter associated with reduced pain perception.

  9. St. John's Wort

    Herb that may inhibit COMT activity similar to some pain medications. Also boosts serotonin which improves mood.

  10. Peppermint oil

    Menthol is a COMT inhibitor. Peppermint oil applied topically may enhance painkilling dopamine effects.

  11. Boswellia

    Anti-inflammatory herb that may disrupt cytokine signaling implicated in pain hypersensitivity.

  12. Cannabidiol (CBD)

    Compound from cannabis that affects endocannabinoid receptors involved in pain processing.

  13. DLPA

    Supplement containing amino acids that may prevent breakdown of endorphins for natural pain relief.

  14. 5-HTP

    Supplement that increases serotonin levels which may help with fibromyalgia and comorbid depression.

  15. Ginger

    Contains anti-inflammatory gingerols that may inhibit pain-causing prostaglandins and leukotrienes.

  16. Arnica

    Homeopathic pain remedy used topically that may reduce inflammation and impact serotonin.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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