Curcumin (turmeric)

Curcumin (turmeric) as it relates to Chronic Pain in Health report: COMT and Chronic Pain Susceptibility

Curcumin, a compound found in the spice turmeric, has been studied for its potential benefits in managing chronic pain.

Anti-inflammatory properties

Curcumin is known for its strong anti-inflammatory properties. Chronic pain conditions such as arthritis, fibromyalgia, and lower back pain are often associated with inflammation in the body. By reducing inflammation, curcumin may help alleviate pain and improve overall quality of life for individuals suffering from chronic pain.

Antioxidant effects

Curcumin also acts as a powerful antioxidant, helping to neutralize harmful free radicals in the body. Free radicals can contribute to chronic pain by causing oxidative stress and damage to cells and tissues. By combating oxidative stress, curcumin may help reduce pain and inflammation associated with chronic pain conditions.

Neuroprotective properties

Studies have shown that curcumin has neuroprotective properties, which may be beneficial for individuals with chronic pain conditions that involve the nervous system, such as neuropathic pain. By protecting nerve cells and supporting healthy brain function, curcumin may help reduce pain and improve nerve function in individuals with chronic pain. Overall, curcumin shows promise as a natural remedy for managing chronic pain due to its anti-inflammatory, antioxidant, and neuroprotective effects. However, it is important to consult with a healthcare provider before using curcumin supplements to ensure safety and effectiveness, especially if you are taking other medications or have underlying health conditions.

Supplements for Chronic Pain

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Curcumin (turmeric)

    Shown to inhibit COMT activity and increase dopamine levels in the brain. Also has anti-inflammatory effects.

  2. Omega-3 fatty acids (fish oil):

    May reduce inflammation that contributes to pain. Also may protect neurons that use dopamine.

  3. Magnesium

    Required for COMT enzymatic reactions. Supplements may help for those deficient.

  4. Rhodiola rosea

    Herb that may inhibit COMT, especially in the Met/Met genotype. May prolong dopamine effects.

  5. SAM-e

    Supplement that provides methyl groups needed for COMT methylation reactions. May support COMT function.

  6. Devil's claw

    Natural anti-inflammatory that may reduce inflammatory pain. Also thought to interact with neurotransmitter systems.

  7. Cayenne/Capsaicin

    Compound found in hot chili peppers that depletes substance P, a neurotransmitter involved in pain signaling.

  8. Valerian root

    Herbal anxiolytic that may increase GABA, a neurotransmitter associated with reduced pain perception.

  9. St. John's Wort

    Herb that may inhibit COMT activity similar to some pain medications. Also boosts serotonin which improves mood.

  10. Peppermint oil

    Menthol is a COMT inhibitor. Peppermint oil applied topically may enhance painkilling dopamine effects.

  11. Boswellia

    Anti-inflammatory herb that may disrupt cytokine signaling implicated in pain hypersensitivity.

  12. Cannabidiol (CBD)

    Compound from cannabis that affects endocannabinoid receptors involved in pain processing.

  13. DLPA

    Supplement containing amino acids that may prevent breakdown of endorphins for natural pain relief.

  14. 5-HTP

    Supplement that increases serotonin levels which may help with fibromyalgia and comorbid depression.

  15. Ginger

    Contains anti-inflammatory gingerols that may inhibit pain-causing prostaglandins and leukotrienes.

  16. Arnica

    Homeopathic pain remedy used topically that may reduce inflammation and impact serotonin.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
Disclaimer