Curcumin (turmeric)
Curcumin (turmeric) as it relates to Chronic Pain in Health report: COMT and Chronic Pain Susceptibility
Anti-inflammatory properties:
Curcumin is known for its strong anti-inflammatory properties, which can help reduce inflammation in the body. Chronic pain conditions, such as arthritis, are often associated with inflammation, and curcumin may help alleviate pain by reducing this inflammation.Antioxidant effects:
Curcumin also acts as an antioxidant, helping to protect the body from oxidative stress. Oxidative stress can contribute to chronic pain conditions, and the antioxidant properties of curcumin may help reduce pain by combating this stress.Neuroprotective effects:
Studies have shown that curcumin has neuroprotective effects, which means it can help protect the nervous system from damage. This is important in the context of chronic pain, as nerve damage or dysfunction can contribute to ongoing pain. By protecting the nerves, curcumin may help alleviate chronic pain symptoms.Enhanced pain relief:
Some research suggests that curcumin may enhance the effects of pain-relieving medications, making them more effective in managing chronic pain. This could be particularly beneficial for individuals who have not found relief with traditional pain medications alone. In conclusion, curcumin, found in turmeric, has shown promise in managing chronic pain due to its anti-inflammatory, antioxidant, and neuroprotective properties. While more research is needed to fully understand its effects, incorporating curcumin into a comprehensive pain management plan may offer some relief for individuals suffering from chronic pain.Supplements for Chronic Pain
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
-
Curcumin (turmeric)
Shown to inhibit COMT activity and increase dopamine levels in the brain. Also has anti-inflammatory effects.
-
Omega-3 fatty acids (fish oil):
May reduce inflammation that contributes to pain. Also may protect neurons that use dopamine.
-
Magnesium
Required for COMT enzymatic reactions. Supplements may help for those deficient.
-
Rhodiola rosea
Herb that may inhibit COMT, especially in the Met/Met genotype. May prolong dopamine effects.
-
SAM-e
Supplement that provides methyl groups needed for COMT methylation reactions. May support COMT function.
-
Devil's claw
Natural anti-inflammatory that may reduce inflammatory pain. Also thought to interact with neurotransmitter systems.
-
Cayenne/Capsaicin
Compound found in hot chili peppers that depletes substance P, a neurotransmitter involved in pain signaling.
-
Valerian root
Herbal anxiolytic that may increase GABA, a neurotransmitter associated with reduced pain perception.
-
St. John's Wort
Herb that may inhibit COMT activity similar to some pain medications. Also boosts serotonin which improves mood.
-
Peppermint oil
Menthol is a COMT inhibitor. Peppermint oil applied topically may enhance painkilling dopamine effects.
-
Boswellia
Anti-inflammatory herb that may disrupt cytokine signaling implicated in pain hypersensitivity.
-
Cannabidiol (CBD)
Compound from cannabis that affects endocannabinoid receptors involved in pain processing.
-
DLPA
Supplement containing amino acids that may prevent breakdown of endorphins for natural pain relief.
-
5-HTP
Supplement that increases serotonin levels which may help with fibromyalgia and comorbid depression.
-
Ginger
Contains anti-inflammatory gingerols that may inhibit pain-causing prostaglandins and leukotrienes.
-
Arnica
Homeopathic pain remedy used topically that may reduce inflammation and impact serotonin.
Disclaimer