DLPA

DLPA as it relates to Chronic Pain in Health report: COMT and Chronic Pain Susceptibility

DLPA, or DL-phenylalanine, is a nutritional supplement that has been studied for its potential benefits in managing chronic pain. DLPA is a combination of two forms of the amino acid phenylalanine: D-phenylalanine and L-phenylalanine.

How DLPA works in Chronic Pain:

DLPA is believed to work by increasing levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine. These neurotransmitters play a role in pain perception and mood regulation. By increasing their levels, DLPA may help reduce pain sensitivity and improve mood in individuals with chronic pain conditions.

Benefits of DLPA in Chronic Pain:

- **Pain Relief:** DLPA has been shown to have analgesic properties, making it potentially beneficial for reducing chronic pain symptoms. - **Mood Enhancement:** By increasing levels of dopamine and norepinephrine, DLPA may also help improve mood and overall well-being in individuals with chronic pain.

Usage and Dosage:

DLPA is typically taken in supplement form, with recommended dosages varying depending on the individual and the specific chronic pain condition being treated. It is important to consult with a healthcare provider before starting DLPA supplementation to determine the appropriate dosage for your needs.

Side Effects:

While DLPA is generally considered safe for most people, some individuals may experience mild side effects such as headaches, nausea, or gastrointestinal discomfort. It is important to discontinue use and consult a healthcare provider if you experience any adverse reactions while taking DLPA. Overall, DLPA shows promise as a natural supplement for managing chronic pain, but more research is needed to fully understand its effectiveness and safety in this context.

Supplements for Chronic Pain

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Curcumin (turmeric)

    Shown to inhibit COMT activity and increase dopamine levels in the brain. Also has anti-inflammatory effects.

  2. Omega-3 fatty acids (fish oil):

    May reduce inflammation that contributes to pain. Also may protect neurons that use dopamine.

  3. Magnesium

    Required for COMT enzymatic reactions. Supplements may help for those deficient.

  4. Rhodiola rosea

    Herb that may inhibit COMT, especially in the Met/Met genotype. May prolong dopamine effects.

  5. SAM-e

    Supplement that provides methyl groups needed for COMT methylation reactions. May support COMT function.

  6. Devil's claw

    Natural anti-inflammatory that may reduce inflammatory pain. Also thought to interact with neurotransmitter systems.

  7. Cayenne/Capsaicin

    Compound found in hot chili peppers that depletes substance P, a neurotransmitter involved in pain signaling.

  8. Valerian root

    Herbal anxiolytic that may increase GABA, a neurotransmitter associated with reduced pain perception.

  9. St. John's Wort

    Herb that may inhibit COMT activity similar to some pain medications. Also boosts serotonin which improves mood.

  10. Peppermint oil

    Menthol is a COMT inhibitor. Peppermint oil applied topically may enhance painkilling dopamine effects.

  11. Boswellia

    Anti-inflammatory herb that may disrupt cytokine signaling implicated in pain hypersensitivity.

  12. Cannabidiol (CBD)

    Compound from cannabis that affects endocannabinoid receptors involved in pain processing.

  13. DLPA

    Supplement containing amino acids that may prevent breakdown of endorphins for natural pain relief.

  14. 5-HTP

    Supplement that increases serotonin levels which may help with fibromyalgia and comorbid depression.

  15. Ginger

    Contains anti-inflammatory gingerols that may inhibit pain-causing prostaglandins and leukotrienes.

  16. Arnica

    Homeopathic pain remedy used topically that may reduce inflammation and impact serotonin.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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