Devil's claw

Devil's claw as it relates to Chronic Pain in Health report: COMT and Chronic Pain Susceptibility

Devil's Claw for Chronic Pain

Devil's claw (Harpagophytum procumbens) is a plant native to southern Africa that has been used for centuries in traditional medicine to treat various ailments, including chronic pain. It is named for the small hooks on its fruit, which resemble claws.

Devil's claw contains active compounds such as harpagoside and harpagide, which have anti-inflammatory and analgesic properties. These compounds are believed to help reduce pain and inflammation in conditions such as arthritis, back pain, and muscle pain.

Studies have shown that devil's claw may be effective in reducing pain and improving mobility in people with chronic pain conditions. It is often used as a natural alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief, as it is generally well-tolerated and has fewer side effects.

It is important to note that devil's claw may interact with certain medications, so it is recommended to consult with a healthcare provider before using it, especially if you are taking other medications or have underlying health conditions.

In conclusion, devil's claw is a natural remedy that shows promise in managing chronic pain. It may be worth considering as part of a comprehensive treatment plan for chronic pain, but always consult with a healthcare provider before starting any new supplement regimen.

Supplements for Chronic Pain

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Curcumin (turmeric)

    Shown to inhibit COMT activity and increase dopamine levels in the brain. Also has anti-inflammatory effects.

  2. Omega-3 fatty acids (fish oil):

    May reduce inflammation that contributes to pain. Also may protect neurons that use dopamine.

  3. Magnesium

    Required for COMT enzymatic reactions. Supplements may help for those deficient.

  4. Rhodiola rosea

    Herb that may inhibit COMT, especially in the Met/Met genotype. May prolong dopamine effects.

  5. SAM-e

    Supplement that provides methyl groups needed for COMT methylation reactions. May support COMT function.

  6. Devil's claw

    Natural anti-inflammatory that may reduce inflammatory pain. Also thought to interact with neurotransmitter systems.

  7. Cayenne/Capsaicin

    Compound found in hot chili peppers that depletes substance P, a neurotransmitter involved in pain signaling.

  8. Valerian root

    Herbal anxiolytic that may increase GABA, a neurotransmitter associated with reduced pain perception.

  9. St. John's Wort

    Herb that may inhibit COMT activity similar to some pain medications. Also boosts serotonin which improves mood.

  10. Peppermint oil

    Menthol is a COMT inhibitor. Peppermint oil applied topically may enhance painkilling dopamine effects.

  11. Boswellia

    Anti-inflammatory herb that may disrupt cytokine signaling implicated in pain hypersensitivity.

  12. Cannabidiol (CBD)

    Compound from cannabis that affects endocannabinoid receptors involved in pain processing.

  13. DLPA

    Supplement containing amino acids that may prevent breakdown of endorphins for natural pain relief.

  14. 5-HTP

    Supplement that increases serotonin levels which may help with fibromyalgia and comorbid depression.

  15. Ginger

    Contains anti-inflammatory gingerols that may inhibit pain-causing prostaglandins and leukotrienes.

  16. Arnica

    Homeopathic pain remedy used topically that may reduce inflammation and impact serotonin.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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