Omega-3 fatty acids (fish oil):

Omega-3 fatty acids (fish oil): as it relates to Chronic Pain in Health report: COMT and Chronic Pain Susceptibility

Omega-3 fatty acids, commonly found in fish oil, have been shown to have numerous health benefits, especially in the context of chronic pain.

Anti-inflammatory properties:

Omega-3 fatty acids are known for their powerful anti-inflammatory effects. Chronic pain is often associated with inflammation in the body, and omega-3s can help reduce this inflammation, leading to a decrease in pain levels.

Neuropathic pain relief:

Studies have shown that omega-3 fatty acids can help alleviate neuropathic pain, which is caused by damage or dysfunction in the nervous system. By reducing inflammation and improving nerve function, omega-3s can provide relief for those suffering from this type of chronic pain.

Improved joint health:

Omega-3 fatty acids have been found to be beneficial for individuals with chronic joint pain, such as arthritis. The anti-inflammatory properties of omega-3s can help reduce pain and stiffness in the joints, improving overall joint health and mobility.

Enhanced mood:

Chronic pain can often lead to feelings of depression and anxiety. Omega-3 fatty acids have been shown to have mood-boosting effects, which can help improve mental well-being in individuals dealing with chronic pain. Incorporating fish oil supplements or increasing consumption of omega-3-rich foods, such as fatty fish like salmon, mackerel, and sardines, can be a natural and effective way to manage chronic pain and improve overall quality of life.

Supplements for Chronic Pain

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Curcumin (turmeric)

    Shown to inhibit COMT activity and increase dopamine levels in the brain. Also has anti-inflammatory effects.

  2. Omega-3 fatty acids (fish oil):

    May reduce inflammation that contributes to pain. Also may protect neurons that use dopamine.

  3. Magnesium

    Required for COMT enzymatic reactions. Supplements may help for those deficient.

  4. Rhodiola rosea

    Herb that may inhibit COMT, especially in the Met/Met genotype. May prolong dopamine effects.

  5. SAM-e

    Supplement that provides methyl groups needed for COMT methylation reactions. May support COMT function.

  6. Devil's claw

    Natural anti-inflammatory that may reduce inflammatory pain. Also thought to interact with neurotransmitter systems.

  7. Cayenne/Capsaicin

    Compound found in hot chili peppers that depletes substance P, a neurotransmitter involved in pain signaling.

  8. Valerian root

    Herbal anxiolytic that may increase GABA, a neurotransmitter associated with reduced pain perception.

  9. St. John's Wort

    Herb that may inhibit COMT activity similar to some pain medications. Also boosts serotonin which improves mood.

  10. Peppermint oil

    Menthol is a COMT inhibitor. Peppermint oil applied topically may enhance painkilling dopamine effects.

  11. Boswellia

    Anti-inflammatory herb that may disrupt cytokine signaling implicated in pain hypersensitivity.

  12. Cannabidiol (CBD)

    Compound from cannabis that affects endocannabinoid receptors involved in pain processing.

  13. DLPA

    Supplement containing amino acids that may prevent breakdown of endorphins for natural pain relief.

  14. 5-HTP

    Supplement that increases serotonin levels which may help with fibromyalgia and comorbid depression.

  15. Ginger

    Contains anti-inflammatory gingerols that may inhibit pain-causing prostaglandins and leukotrienes.

  16. Arnica

    Homeopathic pain remedy used topically that may reduce inflammation and impact serotonin.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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