Aloe vera

Aloe vera as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury

Aloe vera is a popular plant known for its medicinal properties, including its use in treating various skin conditions and promoting wound healing. However, it is important to note that Aloe vera has been associated with cases of Drug-Induced Liver Injury (DILI).

DILI and Aloe vera

Although Aloe vera is generally considered safe for topical use, there have been reported cases of liver injury associated with the ingestion of Aloe vera products. The potential for liver toxicity is believed to be due to the presence of anthraquinones, such as aloin, in Aloe vera. These compounds have been shown to have a laxative effect and may cause damage to the liver when consumed in large amounts or over a prolonged period of time.

Symptoms of Aloe vera-induced DILI

Symptoms of Aloe vera-induced DILI may include jaundice, abdominal pain, nausea, vomiting, and fatigue. It is important to seek medical attention if you experience any of these symptoms after ingesting Aloe vera products.

Preventing Aloe vera-induced DILI

To reduce the risk of Aloe vera-induced DILI, it is important to use Aloe vera products as directed and avoid consuming excessive amounts of Aloe vera. It is also advisable to consult with a healthcare professional before using Aloe vera products, especially if you have a history of liver disease or are taking medications that may interact with Aloe vera.

Overall, while Aloe vera has many potential health benefits, it is important to be aware of the potential risks associated with its use, including the risk of DILI. By using Aloe vera products responsibly and seeking medical advice when needed, you can minimize the risk of liver injury and safely enjoy the benefits of this versatile plant.

Supplements for DILI

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Green tea extract

    Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.

  2. Greater celandine

    Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.

  3. Chaparral

    Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.

  4. Germander

    Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.

  5. Mistletoe

    Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.

  6. Skullcap

    Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.

  7. Valerian

    Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.

  8. Kava kava

    Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.

  9. St. John's wort

    Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.

  10. Ginseng

    Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.

  11. Aloe vera

    Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.

  12. Ashwagandha

    Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.

  13. Andrographis

    Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.

  14. Noni juice

    Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.

  15. Peppermint oil

    Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.

  16. Kratom

    Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.

  17. Ephedra

    Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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