Aloe vera

Aloe vera as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury

Aloe vera is a popular plant known for its medicinal properties, including its use in treating various skin conditions and promoting wound healing. However, it is important to note that Aloe vera has been associated with cases of Drug-Induced Liver Injury (DILI).

DILI and Aloe vera

Drug-Induced Liver Injury (DILI) refers to liver damage caused by medications or herbal supplements. While Aloe vera is generally considered safe for topical use, there have been reported cases of liver injury associated with the ingestion of Aloe vera supplements or extracts.

Mechanism of DILI

The exact mechanism by which Aloe vera may cause liver injury is not fully understood. Some studies suggest that certain compounds in Aloe vera, such as anthraquinones, may have hepatotoxic effects when consumed in large amounts.

Precautions

It is important to exercise caution when using Aloe vera products internally, especially in high doses or for prolonged periods. Individuals with pre-existing liver conditions or those taking medications known to affect the liver should consult a healthcare provider before using Aloe vera supplements.

Conclusion

While Aloe vera is generally safe for topical use, there is a potential risk of liver injury associated with its internal consumption. It is important to be aware of this risk and use Aloe vera products responsibly, following recommended dosages and guidelines.

Supplements for DILI

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Green tea extract

    Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.

  2. Greater celandine

    Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.

  3. Chaparral

    Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.

  4. Germander

    Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.

  5. Mistletoe

    Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.

  6. Skullcap

    Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.

  7. Valerian

    Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.

  8. Kava kava

    Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.

  9. St. John's wort

    Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.

  10. Ginseng

    Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.

  11. Aloe vera

    Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.

  12. Ashwagandha

    Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.

  13. Andrographis

    Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.

  14. Noni juice

    Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.

  15. Peppermint oil

    Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.

  16. Kratom

    Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.

  17. Ephedra

    Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
Disclaimer