Valerian
Valerian as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury
Valerian and DILI
Although Valerian is generally considered safe for most people when taken at recommended doses, there have been rare cases of liver injury associated with its use. Symptoms of Valerian-induced liver injury may include jaundice, abdominal pain, nausea, and fatigue.
It is important to note that the exact mechanism by which Valerian may cause liver injury is not well understood. Some researchers believe that it may be due to the presence of certain compounds in Valerian that can be toxic to the liver.
Preventing Valerian-Induced Liver Injury
To reduce the risk of liver injury associated with Valerian, it is important to follow the recommended dosage guidelines and to only use high-quality supplements from reputable sources. It is also advisable to consult with a healthcare provider before starting any new supplement regimen, especially if you have a history of liver problems or are taking medications that may interact with Valerian.
If you experience any symptoms of liver injury while taking Valerian, such as jaundice or abdominal pain, it is important to stop taking the supplement immediately and seek medical attention.
In conclusion, while Valerian is generally considered safe for most people, there have been rare cases of liver injury associated with its use. By following recommended dosage guidelines and consulting with a healthcare provider, you can reduce the risk of experiencing Valerian-induced liver injury.
Supplements for DILI
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
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Green tea extract
Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.
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Greater celandine
Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.
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Chaparral
Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.
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Germander
Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.
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Mistletoe
Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.
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Skullcap
Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.
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Valerian
Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.
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Kava kava
Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.
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St. John's wort
Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.
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Ginseng
Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.
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Aloe vera
Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.
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Ashwagandha
Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.
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Andrographis
Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.
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Noni juice
Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.
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Peppermint oil
Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.
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Kratom
Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.
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Ephedra
Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.
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