Germander
Germander as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury
Mechanism of DILI
Germander contains various bioactive compounds, such as diterpenoids, that have been implicated in causing liver damage. These compounds can induce oxidative stress, mitochondrial dysfunction, and inflammation in the liver, leading to hepatocyte injury and liver dysfunction.
Clinical Presentation
Patients with germander-induced DILI may present with symptoms such as jaundice, fatigue, abdominal pain, and elevated liver enzymes. In severe cases, acute liver failure and hepatic encephalopathy can occur, necessitating urgent medical intervention.
Diagnosis and Management
Diagnosing germander-induced DILI involves a thorough medical history, physical examination, and laboratory tests to assess liver function. Imaging studies and liver biopsy may be performed to evaluate the extent of liver damage. Treatment typically involves discontinuing the use of germander and providing supportive care to manage symptoms and promote liver regeneration.
Prevention
To prevent germander-induced DILI, it is important to use herbal products cautiously and in moderation. Patients should be educated about the potential risks associated with herbal remedies and advised to consult healthcare professionals before starting any new herbal supplement.
Overall, germander is a plant with potential hepatotoxic effects, and its use should be approached with caution to avoid the development of drug-induced liver injury.Supplements for DILI
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
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Green tea extract
Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.
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Greater celandine
Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.
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Chaparral
Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.
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Germander
Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.
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Mistletoe
Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.
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Skullcap
Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.
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Valerian
Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.
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Kava kava
Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.
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St. John's wort
Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.
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Ginseng
Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.
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Aloe vera
Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.
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Ashwagandha
Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.
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Andrographis
Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.
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Noni juice
Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.
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Peppermint oil
Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.
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Kratom
Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.
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Ephedra
Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.
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