Andrographis

Andrographis as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury

Andrographis is a medicinal herb that has been traditionally used in Ayurvedic and Traditional Chinese Medicine for its various health benefits. In the context of Drug-Induced Liver Injury (DILI), Andrographis has shown potential hepatoprotective effects.

Hepatoprotective Effects of Andrographis:

  • Antioxidant Properties: Andrographis contains compounds that have antioxidant properties, which help in reducing oxidative stress and inflammation in the liver.
  • Anti-inflammatory Effects: The anti-inflammatory properties of Andrographis may help in reducing inflammation in the liver caused by drug-induced damage.
  • Detoxification Support: Andrographis is believed to support the liver's detoxification processes, helping in the elimination of toxins and drugs from the body.
  • Regeneration of Liver Cells: Some studies suggest that Andrographis may promote the regeneration of liver cells, aiding in the repair of damaged liver tissue.
While Andrographis shows promise as a hepatoprotective herb, more research is needed to fully understand its mechanisms of action and effectiveness in preventing and treating Drug-Induced Liver Injury. It is important to consult with a healthcare provider before using Andrographis or any other herbal supplement, especially if you have a liver condition or are taking medications that may interact with it.

Supplements for DILI

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Green tea extract

    Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.

  2. Greater celandine

    Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.

  3. Chaparral

    Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.

  4. Germander

    Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.

  5. Mistletoe

    Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.

  6. Skullcap

    Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.

  7. Valerian

    Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.

  8. Kava kava

    Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.

  9. St. John's wort

    Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.

  10. Ginseng

    Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.

  11. Aloe vera

    Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.

  12. Ashwagandha

    Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.

  13. Andrographis

    Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.

  14. Noni juice

    Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.

  15. Peppermint oil

    Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.

  16. Kratom

    Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.

  17. Ephedra

    Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
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